What were the narrator’s desires in the memoir? What was motivating the narrator to share this particular story with the reader? Often, memoirs can be cathartic for the writer. Perhaps the writer was trying to process a year of grieving and loss, as Didion does in The Year of Magical Thinking, or perhaps the writer was trying to describe a childhood in a concentration camp, as Spiegelman does in his memoir Maus. Consider the motivations of the writer for putting down their story and presenting it to readers.
Use chapter divisions to give the book structure. Chapters are useful because they allow you to move on from discussing certain life periods or events. There's a reason we have the expression that we've "closed a chapter" or "opened a new chapter" in life, and it's even more applicable when discussing an autobiography. Chapter breaks allow you to skip forward 10 years, go back in time, or start describing a new theme without jarring the reader too much.
What's your central conflict? What's the biggest obstacle life presented that took years to overcome or come to terms with? Maybe it's an illness you were diagnosed with at an early age, a relationship wrought with turmoil, a series of career setbacks, a goal you worked for decades to achieve, or any other number of things. Look to your favorite books and movies for more examples of conflicts.

Develop a central theme, main idea or thesis that clearly explains the purpose behind your autobiography. For example, your theme might be about how you overcame obstacles to become a stronger person, or it might explain why a particular passion -- such as mountain climbing or rescuing animals -- is so important to you. Back your theme with details and background information about your life experiences. For example, you might explain that your dad is in the military, so you've had to learn how to adapt quickly to new schools and unfamiliar environments. Or, you might discuss what it was like growing up in a poor, single-parent home, but how your family was always willing to take in injured or stray pets.
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